https://ccstlab.org/news daily 0.75 2026-05-27 https://ccstlab.org/news/template-3 monthly 0.5 2026-05-27 https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/2a69ca42-7d7b-4a57-97c5-67e16761ec25/kinome_dark_.png News - Defeating PIM kinase that promotes tumorigenesis through non-catalytic functions with PROTACs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://ccstlab.org/news/dr-su-joins-ucla-as-an-assistant-professor-in-chemical-and-biomolecular-engineering-24mn2-ygnjw-whzwz-rygb2 monthly 0.5 2026-05-27 https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/2a69ca42-7d7b-4a57-97c5-67e16761ec25/kinome_dark_.png News - Selective Degradation of MLK3 by a Novel PROTAC Limits the Oncogenic Potential of TNBC - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://ccstlab.org/news/dr-su-joins-ucla-as-an-assistant-professor-in-chemical-and-biomolecular-engineering-24mn2-ygnjw-whzwz monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/2a69ca42-7d7b-4a57-97c5-67e16761ec25/kinome_dark_.png News - New Hope for Head and Neck Cancer: Targeting LZK Disrupts Oncogenic c-MYC and Mutant p53 in HNSCC - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://ccstlab.org/news/dr-su-joins-ucla-as-an-assistant-professor-in-chemical-and-biomolecular-engineering-24mn2 monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/2a69ca42-7d7b-4a57-97c5-67e16761ec25/kinome_dark_.png News - Development of Novel LZK-Targeting PROTACs for Head and Neck Cancer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://ccstlab.org/news/tag/small+molecule+inhibitors monthly 0.5 https://ccstlab.org/news/tag/ovarian+cancer monthly 0.5 https://ccstlab.org/news/tag/head+cancer monthly 0.5 https://ccstlab.org/news/tag/cancer+cells monthly 0.5 https://ccstlab.org/news/tag/SUNY monthly 0.5 https://ccstlab.org/news/tag/PROTACs monthly 0.5 https://ccstlab.org/news/tag/john+brognard monthly 0.5 https://ccstlab.org/news/tag/suny+upstate+medical+university monthly 0.5 https://ccstlab.org/news/tag/lung+cancer monthly 0.5 https://ccstlab.org/news/tag/Cancer+Cell+Signaling+and+Therapeutics+Lab monthly 0.5 https://ccstlab.org/news/tag/neck+cancer monthly 0.5 https://ccstlab.org/news/tag/michael+e+connolly monthly 0.5 https://ccstlab.org/news/tag/target+therapies monthly 0.5 https://ccstlab.org/news/tag/antibody-drug+conjugates monthly 0.5 https://ccstlab.org/news/tag/connolly+endowment monthly 0.5 https://ccstlab.org/news/tag/lung+squamous+cell+carcinoma monthly 0.5 https://ccstlab.org/research daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/58e0bc71-1b55-417d-8ca6-63e692236adf/NSD2-Prostate-Cancer.jpg Research https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/1777474725351-9SMBMZT08U5Z6HLC5KSX/unsplash-image-X9Iq79PFif4.jpg Research https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/b6d25b9d-10ab-40b0-b685-442bc97389e3/AI-for-drug-discovery.jpg Research https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/c44fcb63-623c-4455-99c1-4503f9751861/kinome_.png https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/3ef99162-8006-4c38-b20f-4773de96930f/Screenshot+2026-04-29+at+12.09.56%E2%80%AFPM.png Research - Defining LZK as a critical driver of head and neck and esophageal cancers. Elucidate the mechanisms by which this kinase drives cancer cell viability and promote immune evasion, and develop novel treatment approaches to target this kinase including small molecule inhibitors, ADCs, and degraders. Edwards ZC, Trotter EW, Torres-Ayuso P, Chapman P, Wood HM, Nyswaner K, Brognard J. Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53. Cancer Res. 2017 Sep 15;77(18):4961-4972. PMID: 28760853. Funk AL, Katerji M, Afifi M, Nyswaner K, Woodroofe CC, Edwards ZC, Lindberg E, Bergman KL, Gough NR, Rubin MR, Karpińska K, Trotter EW, Dash S, Ries AL, James A, Robinson CM, Difilippantonio S, Karim BO, Chang TC, Chen L, Xu X, Doroshow JH, Ahel I, Marusiak AA, Swenson RE, Cappell SD, Brognard J. Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors. Sci Signal. 2025 Feb 11;18(873):eado2857. PMID: 39933019 Katerji M, Bergman KL, Lindberg E, Rubin MR, Afifi M, Funk AL, Woodroofe CC, Nyswaner K, Karpińska K, Serwa R, Cappell SD, Marusiak A, Swenson RE, Brognard JF. Discovery of potent and selective PROTACs for the protein kinase LZK for the treatment of head and neck cancer. J Biol Chem. 2025 May;301(5):108452. PMID: 40157536. https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/8b60674d-3a69-41de-bad8-71370647d6cb/Screenshot+2026-04-29+at+7.10.10%E2%80%AFPM.png Research - Development of a new class of precision drug-antibody conjugates for cancers of unmet need Ushering in a new era of ADC discovery, our PAC platform leverages small molecule inhibitors as payloads to target multiple oncogenic drivers within the same cancer cell. Designed to overcome resistance and pathway redundancy, PACs combine precise tumor targeting with coordinated inhibition of key signaling pathways—unlocking improved efficacy with reduced systemic toxicity. https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/124ecc2c-c12a-4c5f-bea0-66f7f006bc68/7114076d-d659-4e40-a065-d74744931aeb.png Research - Development of novel PROTACs to target kinases that promote tumorigenesis independent of catalytic activity Ongoing research focused on: Developing a promising PROTAC to target TNK2 as a novel therapeutic target in ovarian cancer and LSCC Designing a degrader targeting PKCι for the treatment of lung cancer in collaboration with Dr. Allan Field at the Mayo clinic Generating a PROTAC targeting SLK in biliary tract and ovarian cancers in collaboration with Dr. Jonathan Hernandez lab at NIH Developing a degrader targeting PARP7 for treatment of numerous cancers with PARP7 amplifications (HNSCC, LSCC, ESCC) in collaboration with Dr. Ivan Ahel at Oxford University Published work on PIM1 PROTAC to prevent the emergence of chemoresistance in prostate cancer https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/1779902905851-U7HT9GOOFXAR3DX7VUQ6/ChatGPT%2BImage%2BApr%2B29%252C%2B2026%252C%2B11_36_32%2BAM.png Research https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/1779902851764-FFJ6BAQMCWZ3BHO5CBN4/ChatGPT%2BImage%2BApr%2B30%252C%2B2026%252C%2B12_15_22%2BPM.png Research https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/1777565994890-ZIO08OCAPDPEDKJS2UQ0/ChatGPT+Image+Apr+30%2C+2026%2C+12_18_59+PM.png Research https://ccstlab.org/publications daily 0.75 2026-05-28 https://images.squarespace-cdn.com/content/v1/69826a0325a79348badc1c33/1771647049132-QRESNXCEI885RR724MBA/blue-blots-acrylic-contemporary-art.jpg Publications 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